Over the years, the analysis of the serum peptidome has been consistently limited for various reasons: enormous complexity, high protein content, concentration, instability of low-abundance proteins or secreted peptides, depletion steps and precipitation methods.
All these problems occurring at different stages ultimately lead to a significant loss of the endogenous peptide biomarker. Moreover, the coexistence of these high abundance proteins hinders the efficient detection of low or very low abundance peptides.
With these problems in mind, ICCVS has developed a novel approach without depleting or precipitating the serum proteome and a direct isolation platform for rapid, comprehensive and reproducible profiling of serum peptides by mass spectrometry.
The invented innovation is globally applicable for the screening of significant peptides from all types of patient blood samples.
