The invention relates to a method and device for determining the dynamics of transport of biologically active substances, in particular drugs administered transdermally.
The solution employs a biological membrane that mimics the epidermal barrier, allowing for precise determination of diffusion coefficients without the need for complex and costly analytical equipment.
The developed method is based on the analysis of changes in contact angles of a test liquid droplet on the membrane surface, enabling real-time monitoring of the penetration dynamics of active substances.
The device designed for this purpose enables dynamic, precise measurements and offers a simpler setup compared to traditional Franz diffusion cells or spectroscopic methods..
Aplication:
- Preclinical drug testing and pharmacokinetics
- Pharmaceutical industry – development of transdermal therapeutic systems (TTS)
- Cosmetic industry – evaluation of skin permeability of active compounds
- Biophysics and biomaterials research
